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However, studies have shown that it acts directly on the pituitary gland and the hypothalamus, as well as GHRH and somatostatin

In late 2024, Zealand Pharma initiated a phase 2b randomized dose-finding obesity and T2DM + obesity clinical trial (ZUPREME-1 and ZUPREME-2) which will evaluate petrelintides efficacy and safety in individuals with obesity in a larger population ( N = 480) [116]

doi: 10.1016/j.ymgme.2022.106978 70 LuoYLiC

Discontinuation rates due to adverse events were 12.2% at the 9 mg dose and 18.2% at the 12 mg dose in TRIUMPH-4

Furthermore, clinically meaningful blood pressure reductions were observed in participants receiving TZP