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In particular, in the overall population, 107 participants experienced an episode of severe hypoglycaemia, with 30 of the cases occurring in a single trial arm wherein participants were randomised to prandial insulin [46]

if the SSA concentration is 1% or more, chromogenic inhibition will occur

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Differences in pharmacokinetic profiles among GLP-1 RAs may also contribute to variability in GI tolerability, with longer-acting agents generally associated with more persistent, though often less intense, symptoms compared with short-acting formulations