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To specifically delineate the contribution of Nrf2 on the protective effect of metformin on OA progression, an MIA-induced OA mouse model was established using Nrf2 KO mice again

Green et al 26 Severe clinical abnormalities should be treated intensively with B 12 , cyanoB 12 or hydroxyB 12 : HydroxyB 12 is commonly used in Europe, often at intervals of 23 months, as it seems to have better retention than cyanoB 12

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In contrast, for wellness use with normal labs, the rationale is weaker and alternatives should be discussed

et al.Glucagon-like peptide-1 receptor: mechanisms and advances in therapy