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"These drugs have the potential to bring about substantial weight loss, particularly in the first year," says Juan Franco, co-lead researcher from Heinrich Heine University Dsseldorf, Germany

Additionally, gastrointestinal side effects are common

The articles make a point that R- Lipoic acid is used, and not S-Lipoic Acid

Allopurinol: clinical considerations in the development and treatment of Stevens-Johnson syndrome, toxic epidermal necrolysis, and other associated drug reactions