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Se vio que mientras GLP-1 tiene efectos glucagonostticos y lipolticos indirectos, el GIP favorece la lipognesis y tiene un rol glucagonotrpico durante la hipoglucemia
Chronically high levels of glucose can lead to obesity, type 2 diabetes, heart disease, and other conditions
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Bulk RNA sequencing revealed that gene expression changes were most pronounced in the MBH, where RAMP1/3 KO mice treated with sCT showed extensive differential expression of over 1,700 genes, while WT mice exhibited comparatively minor transcriptional shifts
Emerging Trends Expanded Clinical Indications: GLP-1 receptor agonists were initially approved for type 2 diabetes in 2005, and their indications have expanded over time
