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The logic behind this approach is that the concomitant activation of GLP1 and estrogen receptors may drive additional favorable effects, when compared with the individual activation of these pathways, which are known to conduct, on their own, beneficial metabolic actions on energy and glucose homeostasis 52

Side Effects Both medications have similar side effects: Nausea Constipation or diarrhea Fatigue Decreased appetite Tirzepatide may cause slightly less gastrointestinal side effects in the first few weeksbut these often improve with time and dose adjustments

GLP-1 drugs lower blood sugar only when it's high, unlike insulin, which works regardless of glucose levels

Compounding pharmacies have been able to step in and fill some of those gaps in the marketplace. Most states have similar compounding rules, though some states including California and Texas are stricter than others

A Danish registry of 84 000 adults on GLP-1 therapy for diabetes or obesity showed a 23 percent lower risk of hospitalizations for alcohol- or drug-related disorders than matched controls on other medications