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For most drugs, this is a predictable obstaclepharmaceutical formulators account for it by increasing the oral dose proportionally

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The benefits below assume treatment performed by an appropriately credentialed clinician using correct technique, dosing, and product

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This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 / 30 days cancel any time Subscribe to this journal Receive 12 print issues and online access 269,00 per year only 22,42 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout References Sanyal, A