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Human adult dermal fibroblasts incubated with GHK-Cu at concentrations of 0.01, 1, and 100 nM demonstrated increased production of both elastin and collagen, with all concentrations increasing TIMP1 expression and low concentrations enhancing MMP1 and MMP2 gene expression
VEGF-mediated angiogenesis restores capillary supply to crushed or transected muscle, which is rate-limiting for repair in larger soft-tissue injuries
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