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Accumulating findings further suggest that intestinal inflammation may trigger misfolding of -synuclein within enteric neurons, enabling its propagation to the brainstem via vagal pathways and providing a mechanistic link between gut pathology and dopaminergic neurodegeneration
Monitor smartly: symptom checks first, labs if clinically indicated
By 2024, 7% of people with obesity were prescribed these drugs, and the rate has continued to increase
If a clinically meaningful increase in heart rate is identified during retatrutide treatment, several management strategies may be considered, depending on the severity of the elevation and the presence of associated symptoms
For preclinical tissue models, stronger evidence would require standardized injury models, blinded outcome assessment, histological confirmation, functional endpoints, and comparison against appropriate positive and negative controls
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