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Glutathione synthesis occurs in two ATP-dependent steps catalyzed by the enzymes gamma-glutamylcysteine ligase (GCL, the rate-limiting step) and glutathione synthetase [2]

In particular, Donohoe, Collins (273) decisively demonstrated that due to undergoing the Warburg effect, colon cancerous cells primarily rely on uptaking glucose instead of butyrate as a primary carbon source for the production of lactate

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Divided into three groups, participants received oral supplementation of GSH (250 mg/d), GSSG (250 mg/d), or a placebo for 12 weeks