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According to some publications, the extent and the intensity of physiological oral mucosal melanin hyperpigmentation increase with age probably owing to the cumulative effects of endogenous and extrinsic melanogenic stimuli, such as inflammatory processes, drugs, tobacco smoke, and recurrent minor functional injuries [4, 6, 11, 13]
Patients with obesity, diabetes, cardiovascular risk, or obesity-related complications may benefit from referral to a primary care clinician, dietitian, or specialist
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Haqq AM, Chung WK, Dollfus H, Haws RM, Martos-Moreno G, Poitou C, et al
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