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In addition, it cannot enter cells intact and must first metabolize to L-cystine before it can be absorbed

Heres how specific conditions can impact the use of B12 shots: Heart Disease: While B12 is essential for overall health, excessive amounts of vitamin B12 in the body may sometimes cause an increase in certain heart disease risk markers, particularly for individuals with pre-existing cardiovascular conditions

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Chauhan et al., 2012)