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The GSH concentration declines slowly over the 48 hour period to about 50% of normal and the rate of GSH export declines to 67% of normal consistent with the experiments reported in [33]
Thus, a systematic review of the efficacy of GLP-1RAs in terms of their effect on the underlying pathology of AD and improvement of cognitive functions, which included 6 articles that met the criteria (4 randomized control studies and 2 protocol studies) [53], indicates that GLP-1RA therapy in AD did not alter -amyloid and tau protein biomarkers and did not improve cognitive abilities, but demonstrated potential metabolic and neuroprotective benefits
doi: 10.1016/j.metabol.2020.154334 17 NiuHRenXTanEWanXWangYShiHet al
Parker-Athill and Tan, 2010
