This once-daily tablet is prescribed as monotherapy or in combination with other diabetes medications when diet, exercise, and existing treatments do not achieve target HbA1c levels
As these options become more widely available, the need for split dosing injectable medications may diminish
It is widely studied in pre-clinical research for its effects on growth factor signalling, angiogenesis, and collagen synthesis
However, when fatty acid delivery exceeds mitochondrial oxidative and redox-buffering capacity, increased electron transport pressure can elevate reactive oxygen species (ROS) production, promote endoplasmic reticulum stress, and increase susceptibility to lipid peroxidation [54, 61,62,63]
Firstly the Review was based on research papers that were very suspect and involved groups of individuals that did not represent a wide cross section of society (the primary study was of mainly elderly males)