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There are no other absolute contraindications reported for hydroxocobalamin use in deficiency states, but caution is advised in individuals with conditions such as early Lebers optic neuropathy (a rare hereditary optic atrophy) due to the theoretical risk of worsening vision

For a person with a confirmed deficiency, the documented dangers of leaving it untreated generally outweigh the rare, minor risks of the injections themselves

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These mechanisms are believed to underpin its geroprotective effects 1

Twenty-four hours after bleeding, iron begins to be released into the brain