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An exploratory analysis of those formerly using insulin in conjunction with GLP-1 receptor agonist (who were originally excluded from the main analysis) showed an increase in HbA1c (1.2%1.3%, P =0.006) (Supplemental Table S1), suggesting that the insulin dose adjustments made after discontinuing GLP-1 receptor agonists were insufficient to maintain glycemic control

In these seven clinical trials, the safety and tolerability of divalproex sodium in pediatric patients were shown to be comparable to those in adults [seeAdverse Reactions (6)]

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This research is the first national-scale Epic Cosmos analysis, to our knowledge, to characterize real-world use of combined GLP-1RA therapy and MBS among adolescents and young adults with obesity, said lead author Sarah Messiah, Ph.D., M.P.H., Professor of Epidemiology and Associate Dean for Research in the Peter ODonnell Jr