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The evidence base has real structure to it: the selectivity profile is established in animal pharmacology, the GH-stimulating mechanism is well-characterized, and human clinical exposure exists through the postoperative ileus trials
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Lebrun C, Alchaar H, Candito M, et al
The first component of CONTRAVE, naltrexone HCI, is an opioid antagonist
GIP is secreted in response to nutrient stimulation and exerts its actions by binding to the GIP receptor (GIPR) expressed by pancreatic islet cells (45), adipocytes (46), bone cells (47), and the CNS (48)
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