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Individual factors including concentration used, baseline skin condition, age, lifestyle, and complementary skincare significantly affect benefit retention creating substantial variation in personal outcomes requiring experimentation for determining optimal individual approach

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[4] Reviews also describe angiogenic effects that the authors argue mirror standard growth factors across multiple tissue types

Sci Transl Med 7(270):270276 Schafer S, de Marvao A, Adami E, Fiedler LR, Ng B, Khin E, Rackham OJ, van Heesch S, Pua CJ, Kui M, Walsh R, Tayal U, Prasad SK, Dawes TJ, Ko NS, Sim D, Chan LL, Chin CW, Mazzarotto F, Barton PJ, Kreuchwig F, de Kleijn DP, Totman T, Biffi C, Tee N, Rueckert D, Schneider V, Faber A, Regitz-Zagrosek V, Seidman JG, Seidman CE, Linke WA, Kovalik JP, ORegan D, Ware JS, Hubner N, Cook SA (2017) Titin-truncating variants affect heart function in disease cohorts and the general population

Tiaminal B12 injections combine thiamine and vitamin B12