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Patients who are pregnant, breastfeeding, have complex medical conditions, untreated sleep disorders, cardiovascular concerns, psychiatric instability, autoimmune concerns, or multiple medication interactions should be especially cautious

Numerous clinical trials on zinc supplementation have been recently conducted or are ongoing 176,177 , but these are not organelle-specific and thus fall outside the scope of this Review

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When prescribed and monitored by a qualified physician and sourced from a licensed pharmacy, peptides have a generally favorable reported safety profile, with mild injection-site reactions being most common

DOI: 10.1172/JCI92390