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They are believed to enhance matrix synthesis, stimulate osteoblast differentiation, and suppress osteoclast activity, offering potential for osteoporosis prevention and treatment (127)

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Nevertheless, if we compare the internal states corresponding to Nrf2Keap1 complexes (Fig 3D), the dissociation model predicts an immediate decrease in the complex upon exposure to DEM followed by a sharp increase in complex formation, while the hinge-latch model predicts a prolonged increase in the complex that starts immediately upon oxidative stress