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Subcutaneous tirzepatide has an absolute bioavailability of approximately 80%

It also targets other cells in the pancreas to stop the glucagon signal for generating glucose in the liver.[ref] In clinical trials, GLP-1 RAs improved lipid profiles, increased satiety, slowed gastric emptying, reduced inflammation, and had neuroprotective effects.[ref] The slowing of gastric emptying and reducing inflammation may play a role in weight loss, along with the decrease in appetite and eating less

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Duration: At least 36 months of regular use is recommended for sustained results, though early improvements may be seen in 812 weeks