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Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications

To resolve the complex crosstalk among these pathways, machine-learning frameworks built on PANoptosis-related risk scores (PRS) comprised of six key hub genes (YWHAH, PRKACB, PSMB9, FAS, GZMA, and CASP1) have revealed extensive molecular co-activation within tubular and interstitial segments, strongly predicting eGFR decline, serum creatinine elevation, and local immune cell recruitment (209)

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Regulation of protein function by glutathionylation

A parallel phenotype was observed in paraquat-treated fly model where Sp administration resulted in lower accumulation of oxygen radicals in mitochondria of brain neurons (Fig