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Notably, similar inhibitions were observed both with the wild type enzyme and its cysteine mutants, suggesting that thiol conjugation is dispensable for GST inactivation by auronofin in contrast to other described targets 103

While moderate alcohol consumption might be safe for some, heavy or regular drinking can interfere with how tacrolimus is processed

These established therapies should generally be considered first-line treatments unless contraindicated or ineffective for individual patients

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