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Although randomized trials are still ongoing in adolescents, recent observational studies suggest semaglutide can be safely initiated in post-pubertal patients over 18 years with prior bariatric surgery [33, 34]

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This can lead to what is known as adult-onset or age-related growth hormone deficiency

When people lose weight quickly whether through GLP-1 medications, bariatric surgery, illness, or crash dieting the body enters a temporary conservation response