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Six months of voluntary wheel running significantly downregulated the expression of Ferritin, HO-1, janus kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3), DMT1, TFR, and hepcidin in the cerebral cortex of five familial Alzheimers disease (5FAD) mice, reduced A and IL-6 levels, inhibited A plaque deposition and neuroinflammation, thereby improving neurological deficits in AD mice (Belaya et al., 2021)

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