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GLP-1R activation increases the recruitment of the fission protein Drp1 to mitochondria and enhances mitophagy, thereby removing damaged organelles and protecting tissues from oxidative stress (Torres et al., 2016)
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The phase 3 programme is expected to provide more robust data on long-term gastrointestinal tolerability, including the durability of symptom resolution and the impact of different titration schedules
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