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Additionally, GIP receptor signaling activates PI3K, MAPK, and phospholipase A2 [103]
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GLP-1 hormone to increase insulin, slow stomach emptying, and reduce appetite.A 2016 landmark SUSTAIN-6 trial, published in The New England Journal of Medicine , found that semaglutide not only reduced HbA1c levels but also led to significant weight reductions and a 26% lower risk of major cardiovascular events in patients with type 2 diabetes
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