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Estrogen has also been reported to enhance transforming growth factor- (TGF-) signaling, which further contributes to osteoclast apoptosis and coupling between bone resorption and formation (18)
The FDA granted the application a Priority Review designation, and the drug also received a Commissioner National Priority Voucher, which could further accelerate the review process
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The first involves the development of direct inhibitors targeting SLC7A11 to impede cystine uptake in cancer cells, thereby diminishing intracellular GSH levels and inducing cancer cell ferroptosis
