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From a clinical perspective, the lack of large-scale human trials means it cannot yet be considered an established therapy

This mechanism plays a role in activating various downstream pathways, including RAS/MAPK, PI3K/AKT, Wnt/-catenin, and JAK/STAT, which are crucial for controlling a range of cellular physiological activities such as differentiation, proliferation, epithelial cell movement, angiogenesis, and EMT [21]

Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised double-blind multicentre trial