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Tirzepatide slows gastric emptying, which can reduce how much oral contraceptive your body absorbs

In 2024, there were 8.4 million prescriptions and $8.6 billion in spending on GLP-1s in Medicaid, and 21.8 million claims and $27.5 billion in gross spending (not excluding rebates) on GLP-1s in Medicare (Figure 1)

But the drugs are deemed generally safe by the FDA, and parents whose kids are taking them, and the doctors prescribing them, say the benefit of preventing or slowing the progression of obesity-related chronic conditions, such as type 2 diabetes and heart disease that worsen with age, outweighs these risks

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In the SURPASS trials, tirzepatide at its highest dose (15 mg weekly) reduced A1C by approximately 2.4%, with average weight losses exceeding 12 kg