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Findings have also shown that some food types such as the Western diet have higher quantities of TMA precursor levels consequently altering TMAO levels in the long term [111]

In this experiment, the high protein diet can promote intestinal secretion of GLP-1, improve FGF21 resistance, upregulate LKB1 to activate the AMPK pathway, downregulate the expression of SERBP-1c mRNA and protein in the liver, and ultimately inhibit liver lipid synthesis [50]

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