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Children with genetic conditions like methylmalonic acidemia need careful vitamin B12 management
The Billon 2025 paper introducing SLU-PP-915 (PMID 41421047) describes the parent compound SLU-PP-332 as lacking oral bioavailability the orally active sibling SLU-PP-915 was developed because of that limitation
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These include: Complete Blood Count (CBC) to check for better anemia Serum Vitamin B12 levels to make sure the dose is right Methylmalonic acid (MMA) and homocysteine levels to see how the body is reacting Reticulocyte count to see how the bone marrow is doing Clinical Improvement Markers We also watch for signs of improvement in how patients feel
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