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Rotigotine is a dopamine agonist, which has promising potential for the treatment of PD [188], but its use is challenging due to the low bioavailability and high first-pass effects after oral administration, as well as application-site reactions after transdermal treatment [189]

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Aib-His-D-2-Nal-D-Phe-Lys-NH Aib refers to -aminoisobutyric acid, while D-2-Nal refers to D-2-naphthylalanine