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This is particularly relevant when we consider GSH pathways, as well as their transcriptional regulator Nrf2, for proliferation, survival and function of T cells, B cells and macrophages (325, 326)
Many people find that the side effects diminish with continued exposure at the same dose, as the body adapts to the new level of receptor activation
Some people notice their appetite increases as the medicine wears off, and any side effects usually settle after stopping
The mix of heat and sweat can get uncomfortable, sometimes making you stop what you're doing to cool down
These outcomes challenge the narrative of inevitable weight rebound and underscore the power of behavior change layered on top of medication, Duffy said
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