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In a landmark Phase 2 trial published in The New England Journal of Medicine in 2023, participants receiving the highest dose of retatrutide (12 mg once weekly) achieved an average body weight reduction of approximately 24% over 48 weeks results that attracted considerable scientific and media attention
10.2174/1574886315999201208212356 63 JelsingJ.VrangN.HansenG.RaunK.Tang-ChristensenM.KnudsenL
This risk is highest during the first few months of GLP-1 therapy when doses are being increased
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