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doi:10.1016/j.jad.2019.08.054 De Hert M, Detraux J, Vancampfort D

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143 Agomelatine activates melatonin pathways, which play an important role in regulating circadian cycles and serotonin signaling, affecting sleep and mood, and also potentially enhancing neurogenesis and neuroplasticity (the ability to form new neuronal connections)

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