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The Three Generations of Incretin Peptide Research The progression from single to dual to triple agonist peptides represents a research trajectory that has played out in roughly ten years: Generation 1 Single GLP-1 Agonists (Semaglutide, Liraglutide, Exenatide) The first incretin peptides to reach broad clinical research were GLP-1 receptor agonists
1 H- 1 H NOESY NMR Spectroscopy The same samples used for the SNAC titration with 50 mM CTAB were also used for the NOESY experiments
Cesar de la Fuente-Nunez acknowledges support by the NIH R35GM138201, and DTRA HDTRA1-21-1-0014
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