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doi:10.1016/S0140-6736(21)02709-4 Frias, J

5.2.2 Improvements in clinical trial design and interpretation of results In improvement of clinical trial designs, considerations could involve conducting multicenter trials, enhancing randomization and double-blind designs, and utilizing more comprehensive outcome evaluation metrics like clinical symptom improvement, changes in inflammatory markers, and periodontal tissue regeneration

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Hormonal fluctuations : GLP-1 receptor agonists influence brain chemistry, which may contribute to changes in mood