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Fatigue and energy effects Tiredness and fatigue are reported by a significant minority of tirzepatide users, and these effects correlate with drug exposure levels

And that could lead to new treatments for alcoholism and other substance use disorders

A systematic review and meta-analysis published in JAMA Internal Medicine in 2022 pooled 76 randomized clinical trials covering 103,371 patients and found that randomization to a GLP-1 receptor agonist was associated with an increased risk of gallbladder or biliary disease (relative risk 1.37

Weight Stigma and Clinical Messaging Weight-centric messaging in healthcare contributes to stigma and harm, and framing thinness as healthier or more desirable reinforces bias and can negatively impact patient care

For tirzepatide users, skipping the loading phase is generally the better choice