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GLP-1 Pipeline Update: November 2025 Quarterly view of the GLP-1 pipeline and anticipated indications Editorial team Maryam Tabatabai, PharmD Editor-In-Chief Associate Vice President, Clinical Information Carole Kerzic, RPh Executive Editor Drug Information Pharmacist Principal Nicole Kjesbo, PharmD, BCPS Executive Editor Clinical Program Development Director Senior, Pipeline DISCLAIMER The drug pipeline is fluid
These medications work by mimicking the action of naturally occurring GLP-1, an incretin hormone released from the intestine in response to food intake
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In addition, GLP-1RAs can effectively upregulate the expression of myogenic regulatory factors MyoD and MyoG, while inhibiting the transcription of key ubiquitin-ligases MAFbx and MuRF1 in muscle atrophy
It does not interfere with neurotoxin mechanisms and may actually improve the quality of new collagen laid down post-procedure
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