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Management includes: Small, protein-focused meals Avoiding high-fat foods during escalation Adequate hydration Proactive constipation management Slower dose progression What should GPs do if weight loss plateaus

Common Early Side Effects Mild nausea Fullness Constipation Slight fatigue When Thyroid Medication Needs Adjustment If symptoms shift or weight drops quickly, labs may need to be rechecked

Access to these drugs is likely to exacerbate inequities, added on to the lack of diversity of the people assessed in the trial

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This effect can be particularly beneficial for patients who seek to manage their weight effectively and sustainably