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The science behind Hydroxocobalamin (B12) and MIC

So, if you take 1,000 mcg (micrograms) of B12, you can absorb 10 mcg of B12, even if your complex absorption pathway is not functioning properly

When you swallow a B12 pill, several steps have to work for it to be absorbed: stomach acid and the enzyme pepsin must release B12 from food or the supplement, the stomach must secrete a protein called intrinsic factor that binds to B12, and the B12-intrinsic factor complex must reach the ileum (the end of the small intestine) where it is finally absorbed

By blocking this enzyme, researchers can observe a significant shift in cellular methyl-donor availability