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Hepatology 64(6):20282037 Wachsmuth HR, Weninger SN, Duca FA (2022) Role of the gutbrain axis in energy and glucose metabolism

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The primary pathway involves activation of GLP-1 receptors located in the myenteric plexus of the enteric nervous system, coupled to Gs protein subunits that activate adenylyl cyclase and increase cyclic adenosine monophosphate (cAMP) levels [14]