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In the United States alone, more than 795,000 people have strokes every year and about 805,000 people have heart attacks

Despite positive antifibrotic results for OCA in the phase 3 REGENERATE trial [196], the lack of MASH resolution and safety profile led to the definite termination of the OCA development program for MASH

Tirzepatide treatment was associated with a lower incidence of hypoglycemia and did not pose an increased cardiovascular risk

Compared with the control group, the triglyceride (TG) content was significantly decreased in the carnitine supplementation group in the liver and muscle in both the feeding and fasting states

Most mild symptoms, such as difficulty sleeping or feeling jittery, can sometimes be improved with dose timing changes or adjusting the medications