Impaired gut barrier function: Gluten or dairy sensitivity can lead to increased intestinal permeability or "leaky gut," which may impair the release of DAO into the intestinal lumen where it is needed to break down histamine
Called Melanitan 1, 2, 3, 4, and 5, each of which is designed to mimic melanocyte-simulating hormone, but each of which activates different receptors to different degrees
Early animal and small human studies suggest it is generally well tolerated in the short term, but we do not yet have large, longterm trials
Timing: 30 minutes before first food or drink of the day, with no more than 4 oz plain water
Clinical Chemistry and Laboratory Medicine 41 (11): 14781488