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Pharmacology Biochemistry and Behavior, 135 , 199-209

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Combining regular treatment with healthy lifestyle practices may help support better long-term health and weight-management outcomes

cAMP signaling through Gs-coupled receptors activates protein kinase A (PKA) and exchange protein directly activated by cAMP (EPAC) signals to potentiate insulin or GLP-1 secretion in pancreatic -cells 29 or intestinal L-cells 30,31

Tirzepatide is known to aid in weight loss efforts by regulating appetite and potentially improving glycemic control, which can reduce excess weight associated with insulin resistance