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Concave down : It is said to be concave down (convex up) at a point if the tangent line lies above the graph in the vicinity of the point

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Aqneursa was well-tolerated, with common side effects being vomiting, abdominal pain, difficulty swallowing and upper respiratory tract infections

(Provides pharmacological details on pyridoxine, including its role as a coenzyme in neurotransmitter synthesis and interactions such as the antagonism of levodopa and reduction of phenytoin levels)