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Also, due to the important role of endothelial dysfunction in CVD, the effects of GLP-1RA on flow-mediated vasodilation (FMD) in patients remain to be investigated for their contribution to the CVD actions of GLP-1RAs
Glycine included to help prevent muscle loss
Cardiovascular outcome trials of tirzepatideSURPASS-CVOT and SUMMIThave shown encouraging signals, with SURPASS-CVOT meeting the prespecified criteria for non-inferiority for MACEs and a 16% reduction in all-cause mortality [86]
Both share a gastrointestinal side-effect profile, with nausea, diarrhoea, constipation and abdominal discomfort most common during dose escalation
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