Other gastrointestinal effects during week one may include: Constipation or diarrhoea bowel habit changes affect roughly 1020% of patients Reduced appetite often marked and may feel unusual initially Indigestion or acid reflux particularly when lying down after eating Fatigue or mild headache possibly related to dietary changes or adjustment period Injection site reactions such as redness, itching, or mild swelling may occur but are generally minor and resolve quickly
This leads to a greater reliance on glycolysis, which serves to not only generate ATP but also metabolic intermediates to feed the pentose phosphate pathway
While these medications don't directly alter thyroid hormone levels, significant weight loss can affect thyroid hormone requirements
Because the medication slows down your digestion, heavy or fatty red meats can stay in your stomach longer, potentially leading to nausea, bloating, or indigestion
Research from Rabobank notes that GLP-1 users want to eat more protein and smaller portions