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In clinical trials, GLP-1 therapies have been shown to 14: Reduce HbA1C (a snapshot of blood sugar over three months) Support weight loss Improve overall metabolic control They are often used when first-line treatments like metformin are not enough, or when weight loss and cardiometabolic risk are key considerations
There's a lot of articles about them
The weight loss and insulin sensitivity improvements associated with orforglipron would be expected to significantly reduce the risk of progression from prediabetes to overt type 2 diabetes
Where many clinicians are landing these days in osteoarthritis care is this: helping patients understand that hurt does not equal harm, that pacing matters, and that exercises can be progressed over time
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